Discovery, Prevention, Therapeutics. One of the Global Center's main R&D strategies is to combine the knowledge and practices of multiple scientific and clinical research disciplines to attack the highly prevalent, complex communication and biomedical problems of hearing impairment, deafness, age-related hearing loss, communication systems, speech perception, and voice quality. These multiple disciplines include audiology, bioengineering, biochemistry, biomedical imaging, cellular and molecular biology, electrical engineering, electrophysiology, gene therapy, genetics, microsystems engineering, neurophysiology, neuroanatomy, psychoacoustics, signal processing, speech science, and voice science.
Publications
Peer-Reviewed Original Research Journal Articles
2020
Anand S, Skowronski MD, Shrivastav R, Eddins DA. (2019) Perceptual and Quantitative Assessment of Dysphonia Across Vowel Categories. J Voice. 33, 473-481.
Dituri, J., Siddiqi, F., Frisina, R.D. (2019- In Press) Heart Rate Variability Analysis as a Means of Real-time Hypercapnia Detection. Undersea and Hyperbaric Medicine. [H Index=38].
Forouzandeh, F.; Zhu, X.; Alfadhel, A.; Ding, B.; Walton, J.P.; Cormier, D.; Frisina, R.D.; Borkholder, D.A. (2019) A nanoliter resolution implantable micropump for murine inner ear drug delivery. J. Controlled Release. 298, 27-37. [Impact Factor ~8]
Hoover EC, Kinney BN, Bell KL, Gallun FJ, Eddins DA. (2019) A Comparison of Behavioral Methods for Indexing the Auditory Processing of Temporal Fine Structure Cues. J Speech Lang Hear Res. 62(6):2018-2034. PMID: 31145649
Kopf, L.M., Skowronski, M.D., Anand, S., Eddins, D.A., & Shrivastav, R. (2019). "The perception of breathiness in the voices of pediatric speakers, J. Voice , 33(2):204-213.
Moudgalya, S.S., Zhu, X., Walton, J.P., Budzevich, M., Cahill, N.D., Frisina, R.D., Wilson, K., Borkholder, D. (2019) Cochlear Pharmacokinetics Micro-Computed Tomography and Learning-Prediction Modeling for Transport Parameter Determination. Hearing Res. 380, 46-59. [Cover Article; Impact Factor ~3]
Ozmeral EJ, Eddins DA, Eddins AC. (2019) Electrophysiological responses to lateral shifts are not consistent with opponent-channel processing of interaural level differences. J Neurophysiol. 2019 Jun 26. doi: 10.1152/jn.00090.2019. [Epub ahead of print]
Williamson, T.T., Ding, B., Zhu, X., Frisina, R.D. (2019) Hormone Replacement Therapy Attenuates Hearing Loss: Mechanisms Involving Estrogen and the IGF-1 Pathway. Aging Cell. 18:e12939; 1-15. https://doi.org/10.1111/acel.12939 [Impact Factor ~8]
2019
Anand S, Skowronski MD, Shrivastav R, Eddins DA. (2019) Perceptual and Quantitative Assessment of Dysphonia Across Vowel Categories. J Voice. 33, 473-481.
Dituri, J., Siddiqi, F., Frisina, R.D. (2019- In Press) Heart Rate Variability Analysis as a Means of Real-time Hypercapnia Detection. Undersea and Hyperbaric Medicine. [H Index=38].
Forouzandeh, F.; Zhu, X.; Alfadhel, A.; Ding, B.; Walton, J.P.; Cormier, D.; Frisina, R.D.; Borkholder, D.A. (2019) A nanoliter resolution implantable micropump for murine inner ear drug delivery. J. Controlled Release. 298, 27-37. [Impact Factor ~8]
Hoover EC, Kinney BN, Bell KL, Gallun FJ, Eddins DA. (2019) A Comparison of Behavioral Methods for Indexing the Auditory Processing of Temporal Fine Structure Cues. J Speech Lang Hear Res. 62(6):2018-2034. PMID: 31145649
Kopf, L.M., Skowronski, M.D., Anand, S., Eddins, D.A., & Shrivastav, R. (2019). "The perception of breathiness in the voices of pediatric speakers, J. Voice , 33(2):204-213.
Moudgalya, S.S., Zhu, X., Walton, J.P., Budzevich, M., Cahill, N.D., Frisina, R.D., Wilson, K., Borkholder, D. (2019) Cochlear Pharmacokinetics Micro-Computed Tomography and Learning-Prediction Modeling for Transport Parameter Determination. Hearing Res. 380, 46-59. [Cover Article; Impact Factor ~3]
Ozmeral EJ, Eddins DA, Eddins AC. (2019) Electrophysiological responses to lateral shifts are not consistent with opponent-channel processing of interaural level differences. J Neurophysiol. 2019 Jun 26. doi: 10.1152/jn.00090.2019. [Epub ahead of print]
Williamson, T.T., Ding, B., Zhu, X., Frisina, R.D. (2019) Hormone Replacement Therapy Attenuates Hearing Loss: Mechanisms Involving Estrogen and the IGF-1 Pathway. Aging Cell. 18:e12939; 1-15. https://doi.org/10.1111/acel.12939 [Impact Factor ~8]
2018
Amanipour, R., Zhu, X., Duvey, G., Celanire, S., Walton, J.P. Frisina, R.D. Noise-Induced Hearing Loss in Mice: Effects of High and Low Levels of Noise Trauma in CBA Mice. (2018). IEEE Conf. Proc. Explore: Engineer. Med. Biol. Soc. 1210-1213.
Anand S, Kopf LM, Shrivastav R, Eddins DA. (2018) Objective Indices of Perceived Vocal Strain. J Voice. pii: S0892-1997(18)30131-0. doi: 10.1016/j.jvoice.2018.06.005. [Epub ahead of print]
Antoine, M.W., Zhu, X., Vijayakumar, S., Arezzo, J.C., McKeehan, N., Zukin, R.S., Borkholder, D., Jones, S., Frisina, R.D. Hιbert, J.M. (2018) Early Uneven Ear Input Induces Long Lasting Differences in Left Right Motor Function. Plos Biology. 6(3): e2002988. https://doi.org/10.1371/journal.pbio.2002988 [Impact Factor ~10]
Ding, B., J.P. Walton, X. Zhu, R.D. Frisina. (2018) Age-related changes in Na, K-ATPase expression, subunit isoform selection and assembly in the stria vascularis lateral wall of mouse cochlea. Hearing Res. 367:59-73. [Impact Factor ~3]
Eddins, A.C., & Eddins, D.A. (2018). Cortical Correlates of Binaural Temporal Processing Deficits in Older Adults. Ear Hearing, 39(3):594-604. [Impact Factor ~3]
Eddins AC, Ozmeral EJ, Eddins DA. (2018) How aging impacts the encoding of binaural cues and the perception of auditory space. Hearing Res. 369:79-89. (Cover article)
Hoover, E.C., Eddins, A.C., & Eddins, D.A. (2018). Distribution of spectral modulation transfer functions in a young, normal-hearing. J. Acoust. Soc. Am. 143(1): 306309.
Ozmeral EJ, Eddins AC, Eddins DA. (2018) How Do Age and Hearing Loss Impact Spectral Envelope Perception? J Speech Lang Hear Res. 61(9):2376-2385. PMID: 30178062
Walton, J.P., A.C. Dziorny, O.N. Vasilyeva, A.E. Luebke (2018) Loss of the Cochlear Amplifier Prestin Reduces Temporal Processing Efficacy in the Central Auditory System. Front Cell Neurosci. 2018; 12: 291. [Impact Factor ~4]
2017
Bazard, P., Frisina, R.D., Walton, J.P., Bhethanabotla, V. (2017- On Line) Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells. Nature- Scientific Reports. [Impact Factor ~5]
Brecht, E.J., K. Barsz, B. Gross, J. P. Walton (2017) Neurobiol. Aging. 2017 Aug; 56: 8799. [Impact Factor ~5]
Watson, N., Ding, B., X. Zhu, R.D. Frisina. (2017) Chronic Inflammation - Inflammaging - in the Ageing Cochlea: A Novel Target for Future Presbycusis Therapy. Aging Res. Rev., 40, 142-148. [Impact Factor ~9]
Wheeler, H.E., Gamazon, E.R., Frisina, R.D., Perez-Cervantes, C., El Charif, O., Mapes, B., Gruener, R.F., Wing, C., Fossa, S.D., Feldman, D.R., Hamilton, R.J., Vaughn, D.J., Beard, C.J., Fung, C., Einhorn, L.H., Kollmannsberger, C., Kim, J., Mushiroda, T., Kubo, K., Ardeshir-Rouhani-Fard, S., Cox, N.J., Dolan, M.E., Travis, L.B. (2017) Variants in WFS1 and other Mendelian deafness genes are associated with cisplatin-associated ototoxicity. Clinical Cancer Res. 23:3325-33. doi: 10.1158/1078-0432.CCR-16-2809. [Impact Factor ~10]
2016
Amanipour, R.A., Cresoe, S., Zhu, X., Parsons, T., Borlongan, C.V., Frisina, R.D., Walton, J.P. (2016) Impact of Mild Traumatic Brain Injury on Auditory Brain Stem Dysfunction in Mouse Model. Proc. IEEE Explore: Engineer. Med. Biol. Soc. 32, 13-14.
Amanipour, R.M., Frisina, R.D., Cresoe, S.A., Parsons, T.J., Zhu, X., Borlongan, C.V., Walton, J.P. (2016) Impact of Mild Traumatic Brain Injury on Auditory Brain Stem Dysfunction in Mouse Model. Proc. IEEE Explore: Engineer. Med. Biol. Soc. 38,, pp. 1854-1857. doi: 10.1109/EMBC.2016.7591081.
Eddins, D. A., Anand, S., Camacho, A., & Shrivastav, R. (2016). Modeling of breathy voice quality using pitch strength estimates. J. Voice, 30(6), 774.e1-774.e7.
Frisina^, R.D., H.E. Wheeler^, S.D. Fossa, S. Kerns, H.D. Sesso, D.R. Feldman, R. Hamilton, D.J. Vaughn, C.J. Beard, C. Fung, A. Budnick, A. Weinzerl, E. Johnson, L.H. Einhorn, N.J. Cox, M.E Dolan, L.B. Travis. (2016) Comprehensive Characterization of Cisplatin-Related Hearing Loss and Tinnitus: Implications for Improved Management and Therapeutics. J. Clinical Oncology. 34(23):2712-20, ^equal 1st authors. with Editorial. [Impact Factor ~25]
Editorial: Oldenburg J, Gietema JA. The Sound of Silence: A Proxy for Platinum Toxicity. J Clin Oncol 2016;34(23):2687-9.
Frisina^, R.D., Ding^, B., X. Zhu, J.P. Walton. (2016 On Line) Age-Related Hearing Loss: Prevention of Threshold Declines, Cell Loss and Apoptosis in Spiral Ganglion Neurons. Aging. ^equal 1st authors. [Impact Factor ~6]
Halonen, J., Hinton, A., Frisina, R.D., Zhu, X., Walton, J.P. (2016) Long-term Treatment with the Mineralocorticoid Aldosterone Slows Down the Progression of Age-Related Hearing Loss Measured Behaviorally. Hearing Res. 336: 63-71. [Impact Factor ~3]
Ozmeral, E.J., Eddins, D.A., & Eddins, A.C. (2016). Reduced temporal processing in older, normal-hearing listeners evident from electrophysiological responses to shifts in interaural time difference. J. Neurophysiol. 116(6): 27202729.
Ozmeral, E.J., Eddins, A.C., Frisina, D.R., Eddins, D.A. (2016). Large cross-sectional study of presbycusis reveals rapid progressive decline in auditory temporal acuity. Neurobiol. Aging 43, 72-78.
2015
Williamson, T.T., Zhu, X., Walton, J.P., Frisina, R.D. (2015) Auditory Brainstem Gap Responses Start to Decline in Middle Age Mice: A Novel Physiological Biomarker for Age-Related Hearing Loss. Cell & Tissue Research. 361, 359-369.
2014
Frisina, D.R. (2014) A Career Considered: From Audiology to Neuroscience. The Hearing Journal. Sept. 33-37.
Ding, B., R.D. Frisina, X. Zhu, Y. Sakai, B. Sokolowski, J.P. Walton (2014) Direct control of Na+-K+-2Cl- co-transport protein (NKCC1) expression with aldosterone. Am. J. Physiol.- Cell Physiol. Endocrinol. Metabolism. 306 (1): C66-75.
Plowman, E.K., Bijangi-Vishehsaraei, K, Halum, S., Cates, D., Hanenberg, H, Domer, A.S, Nolta, JA, Belafsky, P.C. (2014). Autologous Myoblasts Attenuate Atrophy and Improve Tongue Force in a Denervated Tongue Model: A Pilot Study. Laryngoscope. 124(2):E20-26.
Plowman E.K., Maling, N., Thomas, N.J., Fowler, S.C., Kleim, J.A. (2014). Targeted motor rehabilitation dissociates corticobulbar versus corticospinal dysfunction in an animal model of Parkinsons disease. Neural Rehabilitation and Neural Repair. 28(1):85-95.
Tadros, S.F., DSouza, M., Zhu, X., Frisina, R.D. (2014) Age-related gene expression changes for antioxidants in the CBA mouse cochlea. Plos One. 9:e90279, 1-9.
Tang, X., Zhu, X., Ding, B., Walton, J.P., Frisina, R.D., Su, J. (2014) Age-related Hearing Loss: GABA, Nicotinic acetylcholine and NMDA Receptor Expression Changes in Spiral Ganglion Neurons of the Mouse Cochlea. Neuroscience. 259:184-193.
Travis, L.B., Fossa, S.D., Sesso, H.D., Frisina, R.D., Herrmann, D.N., Beard, C.J., Feldman, D.R., Pagliaro, L.C., Miller, R.C., Vaughn, D.J., Einhorn, L.H., Cox, N.J., Dolan, M.E. (2014) Chemotherapy-Induced Peripheral Neuropathy and Ototoxicity: A Paradigm for Translational Genomics. J. Nat. Cancer Inst. 106(5): 1-11.
2013
Belafsky, P.C, Plowman, E.K, Mehdizadeh, O, Cates, D, Domer A., Yen K. (2013). The Upper Esophageal Sphincter (UES) is Not Round: A Pilot Study Evaluating a More Physiologic Approach to UES Dilation. Annals of Otology, Rhinology & Laryngology. 122(4):217-221.
Borkholder, D.A., Zhu, X., Frisina, R.D. (2013) Round Window Membrane Intracochlear Drug Delivery Enhanced by Induced Advection. J. Controlled Release. 174:171176.
Borkholder, D.A., Zhu, X., Frisina, R.D. (2013) Round Window Membrane Intracochlear Drug Delivery Enhanced by Induced Advection. J. Controlled Release. 174:171176.
Cates, D., Plowman,E.K., Mehdizadeh, O., Yen, K., Domer, A., Gilden, M., and Belafsky, P.C. (2013). Geometric morphometric shape analysis in an ovine model confirms that the upper esophageal sphincter is not round. Laryngoscope, 123(3):721-726.
Eddins, D.A., Arnold, M., Klein, A., Ellison, J. (2013). Individual variability in unaided and aided measurement of acceptable noise level," Seminars in Hearing 34, 118-127.
Eddins, D.A., Shrivastav, R., (2013). Psychometric properties associated with perceived vocal roughness using a matching task. J. of the Acoustical Society of America 134(4): EL294EL300.
Frisina, R.D. and Frisina, D.R. (2013). Physiological and Neurobiological Bases of Age-Related Hearing Loss: Biotherapeutic Implications, American J. of Audiology. 22: 299-302.
Haghpanahia, M., Gladstone, M.B., Zhu, X., Frisina, R.D., Borkholder, D.A. (2013) Noninvasive Quantification of Transport through the Murine Cochlea Using Micro-Computed Tomography. Annals Biomedical Engineering. 41: 2130-2142. PMID: 23636576.
Hoy, M., Domer, A., Plowman, E.K., Loch, R., Belafsky, P.C. (2013) Causes and Diagnosis of Dysphagia in a Tertiary Swallow Center. Annals of Otology, Rhinology & Laryngology, 122(5):335-338.
Kopf, L.M., Skowronski, M.D., Shrivastav, R., Eddins, D.A. (2013). "An exciting comparison: ROEX versus compressive gammachirp auditory excitation patterns in models of voice quality," Proceedings of the 10th International Conference on Advances in Quantitative Laryngology, Voice, and Speech Research, June 3-4, 2013, Cincinnati, Ohio, USA.
Plowman E.K., Maling, N., Rivera, B., Larson, K., Thomas, N.J., Fowler, S.C., Manfredsson, F.P., Shrivastav, R., Kleim, J.A. (2013). Differential sensitivity of cranial and limb motor function to nigrostriatal dopamine depletion. Behavioral Brain Research, 237:157-163.
Plowman, E.K., Mehdizadeh O., Leder B., Martino R., Belafsky PC. (2013). A Bibliometric Review of Published Abstracts Presented at the Dysphagia Research Society: 2001-2011. Dysphagia, 28(2):123-130.
Sabin A.T., Clark C.A., Eddins D., Wright, B.A. (2013). "Different patterns of perceptual learning on spectral modulation detection between older hearing-impaired and younger normal-hearing adults," Journal of the Association for Research in Otolaryngology, 14, 283-294.
Shrivastav, R., Eddins, D.A. (2013). "Is breathiness a quality specific to voices or a quality of sounds In general," Proceedings of the 10th International Conference on Advances in Quantitative Laryngology, Voice, and Speech Research, June 3-4, 2013, Cincinnati, Ohio, USA.
Zecker, S.G., H. Hoffman, R.D. Frisina, J. R. Dubno, S. Dhar, M. Wallhagen, Ph.D., N. Kraus, J. W. Griffith, J. P. Walton, D. A. Eddins, C. Newman, Ph.D,8 D. Victorson, C. M. Warrier, R. H. Wilson. (2013) Audition Assessment Using the NIH Toolbox. Neurology. 80(11 Suppl. 3):S45-48.
2012
Eddins, D.A., Liu, C. (2012). "Psychometric properties of the coordinate response measure corpus with various types of background interference," J. of the Acoustical Society of America 131, 177-183.
Frisina, R.D. (2012) Hormones and Hearing: Too Much or Too Little of a Good Thing can be Ototoxic. Seminars in Hearing. 33: 231-241.
Halum, S., Ting, J., Plowman, E.K., Belafsky, P.C., Postma, G., Pitman, M.J., Moscatello, A., Khosla, S., Maronian, N.C., Sinacori, J.T., Ekbom, D.C. & Merati, A. (2012). A Multi-Institutional Analysis of Tracheotomy Complications. Laryngoscope.122 (1): 38-45.
Sabin, A., Eddins, D.A., Wright, B.A. (2012). "Perceptual learning evidence for tuning to spectro-temporal modulation in the human auditory system.” Journal of Neuroscience. 32, 6542-6549.
Lee, L.L., Strathmann, F.G., Gelein, R., Walton, J.P., Mayer-Proschel, M. (2012) Iron deficiency disrupts axon maturation of the developing auditory nerve. Journal of Neuroscience. 32: 5010-5015.
Liu, C., and Eddins, D.A. (2012). "Measurement of stop consonant identification using adaptive tracking procedures," J. of the Acoustical Society of America 123, EL250 EL256.
Newman, D.L., Fisher, L.M., Ohmen, J., Fong, C., Frisina, S.T., Mapes, F., Eddins, D.A., Frisina, D.R., Frisina, R.D., Friedman, R.A. (2012). "GRM7 variants 1 associated with age-related hearing loss based on auditory perception," Hearing Research 294, 125-32.
Orduna, I., Liu, E. H., Church, B. A., Eddins, A. C., & Mercado, E., 3rd. (2012). Evoked-potential changes following discrimination learning involving complex sounds. Clinical Neurophysiology, 123(4): 711-719.
Patel, S.A., Shrivastav, R., and Eddins, D.A. (2012). "Identifying a comparison for matching rough voice quality." Journal of Speech, Language, Hearing Research 55, 1407-22.
Sabin, A., Eddins, D.A., Wright, B.A. (2012). "Perceptual learning of auditory spectral modulation detection," Experimental Brain Research 218, 567-577.
Sabin, A., Eddins, D.A., Wright, B.A. (2012). "Perceptual learning evidence for tuning to spectro-temporal modulation in the human auditory system." Journal of Neurophysiology. 32, 6542-6549.
Shrivastav, R., Anand, S., Eddins, D.A. (2012)."Pitch Strength of Normal and Dysphonic Voices." J. of the Acoustical Society of America 131, 22612269.
2011
Frisina, R.D., Singh, A., Bak, M., Bozorg, S., Seth, R., Zhu, X. (2011) F1 (CBA x C57) mice show superior hearing in old age relative to their parental strains: Hybrid vigor or a new animal model for "Golden Ears"? Neurobiology of Aging. 32: 1716-1724. (PMCID: PMC2891213)
Johnson, D.G., Frisina, R.D., Borkholder, D.A. (2011) In-Plane Biocompatible Microfluidic Interconnects for Implantable Microsystems. IEEE Transactions on Biomedical Engineering. 58: 943-948. (PMID: 21147591)Margolis, R.H., Frisina, R.D., Walton, J.P. (2011) AMTAS® - Automated Method for Testing Auditory Sensitivity: III. Air Conduction Audiograms in Children and Adults. International J. of Audiology. E-Pub. (PMID: 21417674)
Patel, S.A., Shrivastav, R., and Eddins, D.A. (2011) Perceptual distances of breathy voice quality: A comparison of psychophysical methods. Journal of Voice 24(2), 168-177.
Plowman, E.K, Domer, A. & Belafsky P.C. (2011). Central, peripheral and comorbid affects of normal and disordered aging on deglutition. Otorhinolaringologia, 61: 45-52.
Plowman, E.K., Thomas, N.J. & Kleim, J.A. (2011). Unilateral intrastriatal dopamine depletion induces motor impairments and disrupts motor maps. Journal of Parkinson's Disease, 1, 93-100.
Plowman, E.K. and Kleim, J. A. (2011). Behavioral and Neurophysiological Correlates of Striatal Dopamine Depletion: A Rodent Model of Parkinson's Disease. Journal of Communication Disorders, 44(5):549-56.
Plowman, E., Hentz, B. and Ellis, C. (2011). Post-Stroke Aphasia Prognosis: A Review of Patient-Related and Stroke-Related Factors. Journal of Evaluation in Clinical Practice. 18(3):689-94.
Plowman, E.K. & Okun, M.S. (2011). Antiphospholipid syndrome and other lupus-related movement disorders. Handbook of Clinical Neurology, 100, 237-245.
Shrivastav, R., Camacho, A, Patel, S., Eddins, D.A. (2011) A model for the prediction of breathiness in vowels. Journal of the Acoustical Society of America, 125 1605-1615.
Tra, Y., Frisina, R.D. D’Souza, M., (2011) A novel high-throughput analysis approach: Immune response-related genes are up-regulated in age-related hearing loss. Open Access Bioinformatics. 3: 1-16.
2010
Allen, P. D., Eddins, D. A. (2010) Presbycusis phenotypes form a heterogeneous continuum when ordered by degree and configuration of hearing loss. Hearing Research 264, 10 20.
Amin, S.B., Orlando, M., Eddins, A., MacDonald, M., Monczynski, C., Wang, H. (2010). In utero Iron Status and Auditory Neural Maturation in Premature Infants as Evaluated by Auditory Brainstem Response, J. Pediatrics, 156:377-81.
Borkholder, D.A., Zhu, X., Hyatt, B.T., Archilla, A.S., Livingston, W.J., Frisina, R.D. (2010) Murine Intracochlear Drug Delivery: Reducing Concentration Gradients within the Cochlea. Hearing Res. 268: 2-11. (PMID: 20451593; PMCID: PMC2933796)
Charitidi, K., Frisina, R.D., Vasilyeva, O.N., Zhu, X., Canlon, B. (2010) Expression patterns of estrogen receptors in the central auditory system change in prepubertal and aged mice. Neuroscience. 170: 1270-1281. (PMID: 20736049; PMCID: PMC3133947)
Frisina, R.D., Zhu, X. (2010) Auditory sensitivity and the outer hair cell system in the CBA mouse model of age-related hearing loss. Open Access Animal Physiology. 2: 9-16. (PMCID: PMC3159169)
Johnson, D.G., Waldron, M.J., Frisina, R.D., Borkholder, D.A. (2010) Implantable Micropump Technologies for Murine Intracochlear Infusions. IEEE Engineering in Medicine and Biology Society. 6441-6444. (PMID: 21096713; PMCID: PMC3137522)
Plowman, E.K. and Kleim, J.A. (2010). Motor Cortex Reorganization Across the Lifespan. Journal of Communication Disorders 43(4), 286-294.
Polesskaya, O., Cunningham, L.L., Francis, S.P., Luebke, A.E., Zhu, X., Collins, D., Vasilyeva, O.N., Sahler, J., Desmet, E.A., Gelbard, H.A., Maggirwara, S.B., Walton, J.P., Frisina, R.D., Dewhurst, S. (2010). Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure. Hearing Res. 270, 21-27. (PMID: 20971179; PMCID: PMC2997883)
2009
Christensen, N., D'Souza, M., Zhu, X., Zettel, M.L., Frisina, R.D. (2009) Age-related hearing loss: Aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain. Brain Research. 1253: 27-34.
Jones, H. N., Shrivastav, R, Wu, S. S., Plowman-Prine, E. K., & Rosenbek, J. C. (2009). Intensity and fundamental frequency variability before and after two behavioral treatments for aprosodia. Journal of Medical Speech-Language Pathology, 17, 45-53.
Plowman-Prine E.K, Sapienza, C.M, Okun, M.S., Pollock, S.L, Jacobson, C., Wu, S., Rosenbek, J.C. (2009). The Relationship between Quality of Life and Swallowing in Parkinson's Disease. Movement Disorders, 24(9),1352-1358.
Plowman-Prine, E.K., Okun, M.S., Sapienza, C.M., Shrivastav, R., Fernandez, H.H., Foote, K.D., Ellis, C., Rodriguez, A.D., Burkhead, L.M., & Rosenbek, J.C. (2009). Perceptual characteristics of Parkinsonism speech: A comparison of the pharmacological effects of levodopa across speech and non-speech motor systems. Neurorehabilitation, 24, 1-13.
Price, K., Zhu, X., Guimaraes, P., Vasilyeva, O.N., Frisina, R.D. (2009-In Press) Hormone replacement therapy diminishes hearing in perimenopausal mice. Hearing Res.
Saoji, A. A., Litvak, L., Spahr, A. J., and Eddins, D. A. (2009) Spectral envelope perception and vowel and consonant identification in cochlear implant listeners. Journal of the Acoustical Society of America 126, 955-958.
Vasilyeva, O.N., Frisina, S.T., Zhu, X., Walton J. P., Frisina, R.D. (2009) Interactions of hearing loss and diabetes mellitus in the CBA/CaJ mouse model of presbycusis. Hearing Res. 249: 44-53.
2008
Allen P.D., Ison J.R., Walton J.P. (2008) Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levels. Hearing Res. 246: 52-58.
Allen P.D., Schmuck, N., Ison J.R., Walton J.P. (2008) Kv1.1 channel subunits are not necessary for high temporal acuity in behavioral and electrophysiological gap detection. Hear. Res. 246, 52-58.
D'Souza, M., Zhu, X., Frisina, R.D. (2008) Novel approach for selecting genes from RMA normalized microarray data using functional hearing tests in aging mice. J. Neurosci. Methods, 171:279-287.
Liu, C., and Eddins, DA (2008) Effects of Spectral Modulation Filtering on Vowel Identification, J. Acoust. Soc. Am. - JASA 124, 1704-1715.
Liu, C., and Eddins, DA (2008) Categorical dependence of vowel detection in long-term speech-shaped noise, J. Acoust. Soc. Am. - JASA 123, 4539-4546.
Plowman-Prine, E.K., Triggs, W.J., Malcolm, M., & Rosenbek, J.C. (2008). Reliability of Transcranial Magnetic Stimulation for mapping swallowing musculature. Clinical Neurophysiology, 119(10):2298-30.
Qian, J., and Eddins, D. A. (2008) The role of spectral modulation cues in virtual sound localization, J. Acoust. Soc. Am. - JASA 123, 302-314
Tadros, S.F., D'Souza, M., Zhu, X., Frisina, R.D. (2008) Altered Regulation of Apoptosis Pathways with Age and Hearing Loss in the Mouse Cochlea. Apoptosis, 13: 1303-1321.
Walton, J.P., Wilson, W., Barsz, K. (2008) Sensorineural hearing loss and neural correlates of temporal acuity in the inferior colliculus of the C57BL/6 mouse. J. Assoc. Res. Otolaryngol. JARO. 9: 90-101.
2007
Barsz, K., Wilson, W., Walton, J.P. (2007) Reorganization of receptive field maps following hearing loss in inferior colliculus neurons. Neuroscience. 147: 532-545.
Eddins, D. A., and Bero, E. M. (2007). Spectral modulation detection as a function of modulation frequency, carrier bandwidth, and carrier frequency region, J. Acoustical Society of America - JASA, 121 363-372.
El-Badry, M., Ding, D., McFadden, S.L., and Eddins, A.C. (2007). Physiological effects of auditory nerve myelinopathy in Chinchillas. Eur J Neurosci, 25(5): 1437-1446.
Frisina, R.D., Newman, S.R., Zhu, X. (2007) Auditory efferent activation in CBA mice exceeds that of C57s for varying levels of noise. J. Acoustical Society of America - JASA, 121: EL-29-34.
Ison, J. R., Allen, P. D., O'Neill, W. E. (2007) Age-related hearing loss in C57BL/6J mice has both frequency-specific and non-frequency-specific components that produce a hyperacusis-like exaggeration of the acoustic startle reflex. J. Assoc. Res. Otolaryngol.-JARO 8:539-550.
Ison, J. R., Allen, P. D. (2007) Pre- but not post-menopausal female CBA/CaJ mice show less prepulse inhibition than male mice of the same age. Behavioral Brain Res. 185: 76-81.
Johnson, D.G., Zhu, X., Frisina, R.D., Borkholder, D.A. (2007) Micro-Molded Cannulae for Intracochlear Infusions in Small Rodents. 29th IEEE EMBS Annual International Conf. Proc.: Medicine & Biology, 6616-6619.
Jones, L., Prins, J., Park, S., Walton, J.P., Luebke, A. and Lurie, D. (2007) Lead exposure during development results in increased neurofilament phosphorylation, neuritic beading, and temporal processing deficits within the murine auditory brainstem. J. Comp. Neurol. 506: 1003-1017.
Kim, S-H., Frisina, R.D., Frisina, S.T., Mapes, F.M., Hickman, E.D., Frisina, D.R. (2007) Effects of Age and High-Frequency Hearing Loss on Binaural Speech Understanding using HINT. J. Acoust. Soc. (Korea). 26:1-7.
Saoji, A. A., and Eddins, D. A. (2007) Spectral modulation masking patterns reveal tuning to spectral envelope frequency. Journal of the Acoustical Society of America 122, 1004-1013.
Tadros, S.F., D'Souza, M., Zettel, M.L., Zhu, X., Lynch-Erhardt, M., Frisina, R.D. (2007) Serotonin 2B receptor: upregulated with age and hearing loss in mouse auditory system. Neurobiology of Aging, 28: 1112-1123.
Tadros, S.F., D'Souza, M., Zettel, M.L., Zhu, X., Waxmonsky, N.C., Frisina, R.D. (2007) Glutamate-related gene expression in CBA mouse inferior colliculus changes with age and hearing loss. Brain Research. 1127: 1-9.
Zettel, M.L., Zhu, X., O'Neill, W.E., Frisina, R.D. (2007) Age-related declines in Kv 3.1b expression in the mouse auditory brainstem correlate with functional deficits in the medial olivocochlear efferent system. J. Assoc. Res. Otolaryngol. JARO, 8: 280-293.
Zhu, X., Vasilyeva, O., Kim, S-H., Jacobson, M., Romney, J., Waterman, M.S., Tuttle, D., Frisina, R.D. (2007) Auditory efferent system declines precede age-related hearing loss: Contralateral suppression of otoacoustic emissions in mice. J. Comparative Neurology. 503: 593-604.
2006
Bowen, G.P., Ison, J.R. (2006) Excision of visual cortex does not affect the facilitatory and inhibitory effects of a light flash prepulse on the acoustic startle reflex in the rat. Behavioral Brain Research, 168, 114-119.
Frisina, R.D., Walton, J.P. (2006) Age-related structural and functional changes in the cochlear nucleus. Hearing Research, 217:216-233.
Guimaraes, P., Frisina, S.T., Mapes, F., Tadros, S.F., Frisina, D.R., Frisina, R.D. (2006) Progestin negatively affects hearing in aged women. Proc Nat. Acad. Sci. PNAS. 103: 14246-14249.
Frisina, S.T., Mapes, F., Kim, S-H., Frisina, D.R., Frisina, R.D. (2006) Characterization of hearing loss in aged Type II diabetics. Hearing Research. 211:103-113.
Kim, S-H., Frisina, R.D., Mapes, F.M., Hickman, E.D., Frisina, D.R. (2006) Effect of age on binaural speech intelligibility in normal hearing adults. Speech Communication. 48:591-597.
Thompson, S.K., Zhu, X. Frisina, R.D. (2006) Estrogen blockage reduces auditory feedback in CBA mice. Otolaryngology Head and Neck Surgery, 135, 100-105.
2005
Brimijoin, W.O., O'Neill, W.E. (2005) On the prediction of sweep rate and direction selectivity for FM sounds from two-tone interactions in the inferior colliculus. Hearing Res. 210: 6379.
Hammond, G.R., Seth, Y., Ison, J.R. (2005) Concurrent measurement of the detectability of acoustic stimuli and their effect on the excitability of the human blink reflex using a probe-signal method. Hearing Research, 202, 28-34.
Ison, J.R., Allen, P.D., Rivoli, P.J., Moore, J.T. (2005) The behavioral response of mice to gaps in noise depends on its spectral components and its bandwidth. J. Acoust. Soc. Am., 117, 3944-3951.
Tadros, S.F., Frisina, S.T., Mapes, F., Frisina, D.R., Frisina, R.D. (2005) High serum aldosterone levels correlate with lower hearing thresholds in aged humans: A possible protective hormone against presbycusis. Hearing Research. 209:10-18.
Tadros, S., Frisina, S.T., Mapes, F., Kim, S-H., Frisina, D.R., Frisina, R.D. (2005) Loss of peripheral right ear advantage in age-related hearing loss. Audiology & Neuro-Otology, 10:44-52.
Varghese, G.I., Zhu, X., Frisina, R.D. (2005) Age-related declines in contralateral suppression of distortion product otoacoustic emissions utilizing pure tones in CBA/CaJ mice. Hearing Research. 209:60-67.
Review Articles and Book Chapters
2021
Bazard, P., Frisina, R.D., Acosta, A., Dasgupta, S., Bauer, M.A., Zhu, X. and Ding, B. (2021) Roles of Key Ion Channels and Transport Proteins in Age-related Hearing Loss. Int. J. Molecular Sciences. 22(11), 6158. https://doi.org/10.3390/ijms22116158 [Impact Factor ~5] Frisina R.D., Bazard, P., Bauer, M., Pineros, J., Zhu X., Ding, B. (2021) Translational Implications of the Interactions Between Hormones and Age-Related Hearing Loss. Hear. Res. Vol. 402. [Impact Factor ~4]
2017
Frisina, R.D. and D.R. Frisina (2017) Why Does Age-Related Hearing Loss Occur, and What Can Be Done About It? Hearing Health Fn. Frisina, R.D. and D.R. Frisina (2017) Hormone Replacement Therapy and its Effects on Human Hearing. In: Bass, A., Sisneros, J., Popper, A. & Fay, R.R. Eds.; Hormones and Hearing. Springer Science+Business Media, LLC, New York. Ch. 8.
2016
Frisina, R.D. and D.R. Frisina (2016- In Press) Hormone Replacement Therapy and its Effects on Human Hearing. In: Bass, A., Sisneros, J., Popper, A. & Fay, R.R. Eds.; Hormones and Hearing. Springer Science+Business Media, LLC, New York. Ch. 8.
2015
Frisina, R.D. and D.R. Frisina (2015) Genetics of Age-Related Hearing Loss. In: J. Miller, C. Le Prell, L. Rybak, D. Armstrong, Eds. Free Radicals in ENT Pathology: Oxidative Stress in Applied Basic Research and Clinical Practice. Switzerland: Springer-International Press, Ch. 14.
2014
Frisina, D.R. (2014 In Press) Problems Encountered are often Opportunities in Disguise: From Audiology to Administration to Auditory Neuroscience. The Hearing Journal.
2013
Frisina, R.D. and D.R. Frisina (2013) Physiological and Neurobiological Bases of Age-Related Hearing Loss: Biotherapeutic Implications. Am. J. Audiology. 22: 299-302.
2012
[This is an update with final volume & pages] Frisina, R.D. (2012 In Press) Hormones and Hearing: Too Much or Too Little of a Good Thing can be Ototoxic. Seminars in Hearing.33: 231-241.
2010
Eddins, D.A., and Hall, J.W. (2010). "Binaural processing and auditory asymmetries: Temporal resolution in listeners with hearing impairment," In: Gordon-Salant, S., Frisina, R., Popper, A. & Fay, R.R. Eds. The Aging Auditory System: Perceptual Characterization and Neural Bases of Presbycusis. New York: Springer-Verlag
Eddins, A.C. (2010). Hearing Screening. In S. Tanski, L.C. Garfunkel, P.M. Duncan, and M. Weitzman, (Eds). Performing Preventive Services, A Bright Futures Handbook (pp. 129-136) American Academy of Pediatrics.
Frisina, R.D. (2010) Aging, Genetics and Central Auditory Neurobiology. Audiology Today.
Frisina, R.D., Zhu, X. and D'Souza, M. (2010) Biological Bases of Age-Related Hearing Loss. Hearing Care for Adults 2009 The Challenge of Aging, Proceedings of the Phonak Second International Adult Conference.
Frisina, R.D. (2010) Aging Changes in the Central Auditory System. In: Adrian Rees, Alan Palmer Eds. Handbook of Auditory Science: The Auditory Brain. Oxford: Oxford University Press, Ch. 17, pp. 415-436.
Frisina, R.D., Zhu, X. and D'Souza, M. (2010) Biological Bases of Age-Related Hearing Loss. Phonak Proc. Int. Conf. Aging Auditory System, Ch. 2, pp. 19-24.
Gordon-Salant, S., Frisina, R.D., Popper, A. & Fay, R.R. (2010) The Aging Auditory System: Perceptual Characterization and Neural Bases of Presbycusis. New York: Springer-Verlag, 301 pp.
Gordon-Salant, S., Frisina, R.D. (2010) Introduction and Overview. In: Gordon-Salant, S., Frisina, R.D., Popper, A. & Fay, R.R. Eds. The Aging Auditory System: Perceptual Characterization and Neural Bases of Presbycusis. New York: Springer-Verlag, Ch. 1.
Ison, J.R., Tremblay, K., Allen, P.D. (2010). Closing the Gap between Neurobiology and Human Presbycusis: Behavioral and Evoked Potential Studies of Age-related Hearing Loss in Animal Models and in Humans, In: Gordon-Salant, S., Frisina, R.D., Popper, A. & Fay, R.R. Eds. Aging and the Auditory System: Perceptual Characterization and Neural Bases of Presbycusis. New York: Springer-Verlag.
2009
Canlon, B. & Frisina, R.D. (2009) Sex Hormones and Hearing: A Pioneering Area of Enquiry, Co-Editors, Special Issue of Hearing Research on Sex Hormones and Hearing, Vol. 252: 1-2. (PMCID: PMC2758054)
Frisina, R.D. (2009) Age-Related Hearing Loss: Ear and Brain Mechanisms. Annals New York Academy of Sciences. 1170: 708717.
2008
Hayes, D., and Eddins, D. A. (2008) Premium Product Comparison: Does Philosophy Impact Perception? The Hearing Review: Dec.
Ohlemiller, K.K. & Frisina, R.D. (2008) Clinical Characterization of Age-Related Hearing Loss and Its Neural and Molecular Bases. In: J. Schacht, A. Popper, R. Fay eds. Auditory Trauma, Protection and Treatment. New York: Springer-Verlag. Ch. 6, pp.145-194.
Vasilyeva, O.N., Frisina, S.T., Frisina, R.D. (2008) Multidisciplinary Studies Can Help Uncover Mechanisms of Age-Related Hearing Loss in Diabetics. Hearing Health, Deafness Research Foundation, Summer, pp. 43-45.
2007
Frisina, R.D. (2007) Hearing and Medicine as we Age. Am. Hearing Research Fn. Newsletter, 39.
Salvi, R.J. Eddins, A.C., and Wang, J. (2007). Cochlear Physiology II: Mostly Electrophysiology. In F. Musiek and J. Baran (eds). The Auditory System: Anatomy, Physiology, and Clinical Correlates (pp.112-149). Pearson, Allyn & Bacon.
2006
Frisina, R.D., Frisina, D.R. (2006) Methods for studying hearing impairment and auditory problems of the aged. In: Michael Conn. ed. Handbook of Models for Human Aging. Amsterdam: Elsevier, pp. 911-922, Ch. 76.
Frisina, R.D. (2006) Can we Identify Genes that Contribute to Age-Related Hearing Loss? Am. Hearing Research Foundation Newsletter, 38, 4.
Frisina, R.D. (2006) Conversation Age-related hearing loss. Long-Term Care Interface, 7, 26-27.
2005
Frisina, R.D. (2005) Age-Related Hearing Loss: Can the Cochlear Battery be Recharged in Presbycusis? Am. Hearing Research Foundation Newsletter, 37, 2.
Frisina, R.D., Rajan, R. (2005) Inferior Colliculus: Aging and Plasticity. In: Winer J. and Schreiner, C. eds. The Inferior Colliculus. New York: Springer, Ch. 18, pp. 559-584.
Frisina, R.D., D'Souza, M. (2005) Optimizing applications of gene expression microarrays for investigations of the auditory system. Assoc. Res. Otolaryngol. Short Course Handbook.
Frisina, D.R., Frisina, R.D. (2005) The neural and genetic bases of age-related hearing loss. NTID Research Bulletin, 10:1-4.