College of Engineering @ USF College of Behavioral & Community Sciences @ USF
Global Center for Hearing and Speech Research

Discovery, Prevention, Therapeutics. One of the Global Center's main R&D strategies is to combine the knowledge and practices of multiple scientific and clinical research disciplines to attack the highly prevalent, complex communication and biomedical problems of hearing impairment, deafness, age-related hearing loss, communication systems, speech perception, and voice quality. These multiple disciplines include audiology, bioengineering, biochemistry, biomedical imaging, cellular and molecular biology, electrical engineering, electrophysiology, gene therapy, genetics, microsystems engineering, neurophysiology, neuroanatomy, psychoacoustics, signal processing, speech science, and voice science.


United States

Sunol, A.K., Passaglia, C., Jacobson, T., Rogers, E., Guardiano, S., Ticknor, E., Cogswell, K., Frisina, R.D. (2015- In Prep) Bio-Medically Triggered Flotation Textile.

Provisional: Bazard, P., Frisina, R.D., Walton, J.P., Bhethanabotla, V.R. (2015- In Prep) Plasmonic stimulation of electrically excitable biological cells.

Provisional: Rigaud, E., Frisina, R.D., Bhethanabotla, V.R, Davis, G.R., Illig, K.A. (2015) Novel Guidewire Torque Device for Vascular Surgery.

Pending: Frisina, R.D., Walton, J.P., Ding, B., Zhu, X. (2015) Hormone Treatment for Age-Related Hearing Loss- Presbycusis.

Walton, J.P., Miller, K., Taylor, J., Fuller, L. & Frisina, R.D. “Aid to Hearing Speech in a Noisy Environment”, Patent#: 5,285,502 (February 1994).

Miller, K., Fuller, L., Taylor, J., Frisina, R.D. & Walton, J.P.  “Hearing Aid with a Permanently-Adjusted Frequency Response”, Patent#:  5,406,633 (April, 1995).


Walton, J.P., Miller, K., Taylor, J., Fuller, L., & Frisina, R.D. “Aid to Hearing Speech in a Noisy Environment”, Serial#: PCT/US 93908361.4 (1996).


Eddins, D.A., Liu, C. (2012). "Psychometric properties of the coordinate response measure corpus with various types of background interference," J. of the Acoustical Society of America 131, 177-183.

Frisina, R.D. (2012) Hormones and Hearing: Too Much or Too Little of a Good Thing can be Ototoxic. Seminars in Hearing. 33: 231-241.

Halum, S., Ting, J., Plowman, E.K., Belafsky, P.C., Postma, G., Pitman, M.J., Moscatello, A., Khosla, S., Maronian, N.C., Sinacori, J.T., Ekbom, D.C. & Merati, A. (2012). A Multi-Institutional Analysis of Tracheotomy Complications. Laryngoscope.122 (1): 38-45.

Sabin, A., Eddins, D.A., Wright, B.A. (2012). "Perceptual learning evidence for tuning to spectro-temporal modulation in the human auditory system.” Journal of Neuroscience. 32, 6542-6549.

Lee, L.L., Strathmann, F.G., Gelein, R., Walton, J.P., Mayer-Proschel, M. (2012) Iron deficiency disrupts axon maturation of the developing auditory nerve. Journal of Neuroscience. 32: 5010-5015.

Liu, C., and Eddins, D.A. (2012). "Measurement of stop consonant identification using adaptive tracking procedures," J. of the Acoustical Society of America 123, EL250 – EL256.

Newman, D.L., Fisher, L.M., Ohmen, J., Fong, C., Frisina, S.T., Mapes, F., Eddins, D.A., Frisina, D.R., Frisina, R.D., Friedman, R.A. (2012). "GRM7 variants 1 associated with age-related hearing loss based on auditory perception," Hearing Research 294, 125-32.

Orduna, I., Liu, E. H., Church, B. A., Eddins, A. C., & Mercado, E., 3rd. (2012). Evoked-potential changes following discrimination learning involving complex sounds. Clinical Neurophysiology, 123(4): 711-719.

Patel, S.A., Shrivastav, R., and Eddins, D.A. (2012). "Identifying a comparison for matching rough voice quality." Journal of Speech, Language, Hearing Research 55, 1407-22.

Sabin, A., Eddins, D.A., Wright, B.A. (2012). "Perceptual learning of auditory spectral modulation detection," Experimental Brain Research 218, 567-577.

Sabin, A., Eddins, D.A., Wright, B.A. (2012). "Perceptual learning evidence for tuning to spectro-temporal modulation in the human auditory system." Journal of Neurophysiology. 32, 6542-6549.

Shrivastav, R., Anand, S., Eddins, D.A. (2012)."Pitch Strength of Normal and Dysphonic Voices." J. of the Acoustical Society of America 131, 2261–2269.


Frisina, R.D., Singh, A., Bak, M., Bozorg, S., Seth, R., Zhu, X. (2011) F1 (CBA x C57) mice show superior hearing in old age relative to their parental strains: Hybrid vigor or a new animal model for "Golden Ears"?  Neurobiology of Aging. 32: 1716-1724. (PMCID:  PMC2891213)

Johnson, D.G., Frisina, R.D., Borkholder, D.A.  (2011) In-Plane Biocompatible Microfluidic Interconnects for Implantable Microsystems.  IEEE Transactions on Biomedical Engineering. 58: 943-948. (PMID: 21147591)

Margolis, R.H., Frisina, R.D., Walton, J.P.  (2011)  AMTAS® - Automated Method for Testing Auditory Sensitivity:  III. Air Conduction Audiograms in Children and Adults.  International J. of Audiology. E-Pub. (PMID: 21417674)

Patel, S.A., Shrivastav, R., and Eddins, D.A. (2011)  Perceptual distances of breathy voice quality: A comparison of psychophysical methods.  Journal of Voice 24(2), 168-177.

Plowman, E.K, Domer, A. & Belafsky P.C. (2011). Central, peripheral and comorbid affects of normal and disordered aging on deglutition. Otorhinolaringologia, 61: 45-52.

Plowman, E.K., Thomas, N.J. & Kleim, J.A. (2011). Unilateral intrastriatal dopamine depletion induces motor impairments and disrupts motor maps. Journal of Parkinson's Disease, 1, 93-100.

Plowman, E.K. and Kleim, J. A. (2011). Behavioral and Neurophysiological Correlates of Striatal Dopamine Depletion: A Rodent Model of Parkinson's Disease. Journal of Communication Disorders, 44(5):549-56.

Plowman, E., Hentz, B. and Ellis, C. (2011). Post-Stroke Aphasia Prognosis: A Review of Patient-Related and Stroke-Related Factors. Journal of Evaluation in Clinical Practice. 18(3):689-94.

Plowman, E.K. & Okun, M.S. (2011). Antiphospholipid syndrome and other lupus-related movement disorders. Handbook of Clinical Neurology, 100, 237-245.

Shrivastav, R., Camacho, A, Patel, S., Eddins, D.A. (2011)  A model for the prediction of breathiness in vowels.  Journal of the Acoustical Society of America, 125 1605-1615.

Tra, Y., Frisina, R.D. D’Souza, M., (2011) A novel high-throughput analysis approach:  Immune response-related genes are up-regulated in age-related hearing loss. Open Access Bioinformatics.  3: 1-16.


Allen, P. D., Eddins, D. A. (2010) Presbycusis phenotypes form a heterogeneous continuum when ordered by degree and configuration of hearing loss. Hearing Research 264, 10 – 20.

Amin, S.B., Orlando, M., Eddins, A., MacDonald, M., Monczynski, C., Wang, H. (2010). In utero Iron Status and Auditory Neural Maturation in Premature Infants as Evaluated by Auditory Brainstem Response, J. Pediatrics, 156:377-81.

Borkholder, D.A., Zhu, X., Hyatt, B.T., Archilla, A.S., Livingston, W.J., Frisina, R.D. (2010) Murine Intracochlear Drug Delivery: Reducing Concentration Gradients within the Cochlea. Hearing Res. 268: 2-11. (PMID: 20451593; PMCID: PMC2933796)

Charitidi, K., Frisina, R.D., Vasilyeva, O.N., Zhu, X., Canlon, B. (2010) Expression patterns of estrogen receptors in the central auditory system change in prepubertal and aged mice. Neuroscience. 170: 1270-1281. (PMID: 20736049; PMCID: PMC3133947)

Frisina, R.D., Zhu, X. (2010) Auditory sensitivity and the outer hair cell system in the CBA mouse model of age-related hearing loss. Open Access Animal Physiology. 2: 9-16. (PMCID: PMC3159169)

Johnson, D.G., Waldron, M.J., Frisina, R.D., Borkholder, D.A. (2010) Implantable Micropump Technologies for Murine Intracochlear Infusions. IEEE Engineering in Medicine and Biology Society. 6441-6444. (PMID: 21096713; PMCID: PMC3137522)

Plowman, E.K. and Kleim, J.A. (2010). Motor Cortex Reorganization Across the Lifespan. Journal of Communication Disorders 43(4), 286-294.

Polesskaya, O., Cunningham, L.L., Francis, S.P., Luebke, A.E., Zhu, X., Collins, D., Vasilyeva, O.N., Sahler, J., Desmet, E.A., Gelbard, H.A., Maggirwara, S.B., Walton, J.P., Frisina, R.D., Dewhurst, S. (2010). Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure. Hearing Res. 270, 21-27. (PMID: 20971179; PMCID: PMC2997883)


Christensen, N., D'Souza, M., Zhu, X., Zettel, M.L., Frisina, R.D. (2009) Age-related hearing loss: Aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain. Brain Research. 1253: 27-34.

Jones, H. N., Shrivastav, R, Wu, S. S., Plowman-Prine, E. K., & Rosenbek, J. C. (2009). Intensity and fundamental frequency variability before and after two behavioral treatments for aprosodia. Journal of Medical Speech-Language Pathology, 17, 45-53.

Plowman-Prine E.K, Sapienza, C.M, Okun, M.S., Pollock, S.L, Jacobson, C., Wu, S., Rosenbek, J.C. (2009). The Relationship between Quality of Life and Swallowing in Parkinson's Disease. Movement Disorders, 24(9),1352-1358.

Plowman-Prine, E.K., Okun, M.S., Sapienza, C.M., Shrivastav, R., Fernandez, H.H., Foote, K.D., Ellis, C., Rodriguez, A.D., Burkhead, L.M., & Rosenbek, J.C. (2009). Perceptual characteristics of Parkinsonism speech: A comparison of the pharmacological effects of levodopa across speech and non-speech motor systems. Neurorehabilitation, 24, 1-13.

Price, K., Zhu, X., Guimaraes, P., Vasilyeva, O.N., Frisina, R.D. (2009-In Press) Hormone replacement therapy diminishes hearing in perimenopausal mice. Hearing Res.

Saoji, A. A., Litvak, L., Spahr, A. J., and Eddins, D. A. (2009) Spectral envelope perception and vowel and consonant identification in cochlear implant listeners. Journal of the Acoustical Society of America 126, 955-958.

Vasilyeva, O.N., Frisina, S.T., Zhu, X., Walton J. P., Frisina, R.D. (2009) Interactions of hearing loss and diabetes mellitus in the CBA/CaJ mouse model of presbycusis. Hearing Res. 249: 44-53.


Allen P.D., Ison J.R., Walton J.P. (2008) Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levels. Hearing Res. 246: 52-58.

Allen P.D., Schmuck, N., Ison J.R., Walton J.P. (2008) Kv1.1 channel subunits are not necessary for high temporal acuity in behavioral and electrophysiological gap detection. Hear. Res. 246, 52-58.

D'Souza, M., Zhu, X., Frisina, R.D. (2008) Novel approach for selecting genes from RMA normalized microarray data using functional hearing tests in aging mice. J. Neurosci. Methods, 171:279-287.

Liu, C., and Eddins, DA (2008) Effects of Spectral Modulation Filtering on Vowel Identification, J. Acoust. Soc. Am. - JASA 124, 1704-1715.

Liu, C., and Eddins, DA (2008) Categorical dependence of vowel detection in long-term speech-shaped noise, J. Acoust. Soc. Am. - JASA 123, 4539-4546.

Plowman-Prine, E.K., Triggs, W.J., Malcolm, M., & Rosenbek, J.C. (2008). Reliability of Transcranial Magnetic Stimulation for mapping swallowing musculature. Clinical Neurophysiology, 119(10):2298-30.

Qian, J., and Eddins, D. A. (2008) The role of spectral modulation cues in virtual sound localization, J. Acoust. Soc. Am. - JASA 123, 302-314

Tadros, S.F., D'Souza, M., Zhu, X., Frisina, R.D. (2008) Altered Regulation of Apoptosis Pathways with Age and Hearing Loss in the Mouse Cochlea. Apoptosis, 13: 1303-1321.

Walton, J.P., Wilson, W., Barsz, K. (2008) Sensorineural hearing loss and neural correlates of temporal acuity in the inferior colliculus of the C57BL/6 mouse. J. Assoc. Res. Otolaryngol. – JARO. 9: 90-101.


Barsz, K., Wilson, W., Walton, J.P. (2007) Reorganization of receptive field maps following hearing loss in inferior colliculus neurons. Neuroscience. 147: 532-545.

Eddins, D. A., and Bero, E. M. (2007). Spectral modulation detection as a function of modulation frequency, carrier bandwidth, and carrier frequency region, J. Acoustical Society of America - JASA, 121 363-372.

El-Badry, M., Ding, D., McFadden, S.L., and Eddins, A.C. (2007). Physiological effects of auditory nerve myelinopathy in Chinchillas. Eur J Neurosci, 25(5): 1437-1446.

Frisina, R.D., Newman, S.R., Zhu, X. (2007) Auditory efferent activation in CBA mice exceeds that of C57s for varying levels of noise. J. Acoustical Society of America - JASA, 121: EL-29-34.

Ison, J. R., Allen, P. D., O'Neill, W. E. (2007) Age-related hearing loss in C57BL/6J mice has both frequency-specific and non-frequency-specific components that produce a hyperacusis-like exaggeration of the acoustic startle reflex. J. Assoc. Res. Otolaryngol.-JARO 8:539-550.

Ison, J. R., Allen, P. D. (2007) Pre- but not post-menopausal female CBA/CaJ mice show less prepulse inhibition than male mice of the same age. Behavioral Brain Res. 185: 76-81.

Johnson, D.G., Zhu, X., Frisina, R.D., Borkholder, D.A. (2007) Micro-Molded Cannulae for Intracochlear Infusions in Small Rodents. 29th IEEE EMBS Annual International Conf. Proc.: Medicine & Biology, 6616-6619.

Jones, L., Prins, J., Park, S., Walton, J.P., Luebke, A. and Lurie, D. (2007) Lead exposure during development results in increased neurofilament phosphorylation, neuritic beading, and temporal processing deficits within the murine auditory brainstem. J. Comp. Neurol. 506: 1003-1017.

Kim, S-H., Frisina, R.D., Frisina, S.T., Mapes, F.M., Hickman, E.D., Frisina, D.R. (2007) Effects of Age and High-Frequency Hearing Loss on Binaural Speech Understanding using HINT. J. Acoust. Soc. (Korea). 26:1-7.

Saoji, A. A., and Eddins, D. A. (2007) Spectral modulation masking patterns reveal tuning to spectral envelope frequency. Journal of the Acoustical Society of America 122, 1004-1013.

Tadros, S.F., D'Souza, M., Zettel, M.L., Zhu, X., Lynch-Erhardt, M., Frisina, R.D. (2007) Serotonin 2B receptor: upregulated with age and hearing loss in mouse auditory system. Neurobiology of Aging, 28: 1112-1123.

Tadros, S.F., D'Souza, M., Zettel, M.L., Zhu, X., Waxmonsky, N.C., Frisina, R.D. (2007) Glutamate-related gene expression in CBA mouse inferior colliculus changes with age and hearing loss. Brain Research. 1127: 1-9.

Zettel, M.L., Zhu, X., O'Neill, W.E., Frisina, R.D. (2007) Age-related declines in Kv 3.1b expression in the mouse auditory brainstem correlate with functional deficits in the medial olivocochlear efferent system. J. Assoc. Res. Otolaryngol. – JARO, 8: 280-293.

Zhu, X., Vasilyeva, O., Kim, S-H., Jacobson, M., Romney, J., Waterman, M.S., Tuttle, D., Frisina, R.D. (2007) Auditory efferent system declines precede age-related hearing loss: Contralateral suppression of otoacoustic emissions in mice. J. Comparative Neurology. 503: 593-604.


Bowen, G.P., Ison, J.R. (2006) Excision of visual cortex does not affect the facilitatory and inhibitory effects of a light flash prepulse on the acoustic startle reflex in the rat. Behavioral Brain Research, 168, 114-119.

Frisina, R.D., Walton, J.P. (2006) Age-related structural and functional changes in the cochlear nucleus. Hearing Research, 217:216-233.

Guimaraes, P., Frisina, S.T., Mapes, F., Tadros, S.F., Frisina, D.R., Frisina, R.D. (2006) Progestin negatively affects hearing in aged women. Proc Nat. Acad. Sci. – PNAS. 103: 14246-14249.

Frisina, S.T., Mapes, F., Kim, S-H., Frisina, D.R., Frisina, R.D. (2006) Characterization of hearing loss in aged Type II diabetics. Hearing Research. 211:103-113.

Kim, S-H., Frisina, R.D., Mapes, F.M., Hickman, E.D., Frisina, D.R. (2006) Effect of age on binaural speech intelligibility in normal hearing adults. Speech Communication. 48:591-597.

Thompson, S.K., Zhu, X. Frisina, R.D. (2006) Estrogen blockage reduces auditory feedback in CBA mice. Otolaryngology – Head and Neck Surgery, 135, 100-105.


Brimijoin, W.O., O'Neill, W.E. (2005) On the prediction of sweep rate and direction selectivity for FM sounds from two-tone interactions in the inferior colliculus. Hearing Res. 210: 63–79.

Hammond, G.R., Seth, Y., Ison, J.R. (2005) Concurrent measurement of the detectability of acoustic stimuli and their effect on the excitability of the human blink reflex using a probe-signal method. Hearing Research, 202, 28-34.

Ison, J.R., Allen, P.D., Rivoli, P.J., Moore, J.T. (2005) The behavioral response of mice to gaps in noise depends on its spectral components and its bandwidth. J. Acoust. Soc. Am., 117, 3944-3951.

Tadros, S.F., Frisina, S.T., Mapes, F., Frisina, D.R., Frisina, R.D. (2005) High serum aldosterone levels correlate with lower hearing thresholds in aged humans: A possible protective hormone against presbycusis. Hearing Research. 209:10-18.

Tadros, S., Frisina, S.T., Mapes, F., Kim, S-H., Frisina, D.R., Frisina, R.D. (2005) Loss of peripheral right ear advantage in age-related hearing loss. Audiology & Neuro-Otology, 10:44-52.

Varghese, G.I., Zhu, X., Frisina, R.D. (2005) Age-related declines in contralateral suppression of distortion product otoacoustic emissions utilizing pure tones in CBA/CaJ mice. Hearing Research. 209:60-67.